Description

PRAME (Preferentially Expressed Antigen in Melanoma) is a nuclear protein that functions as a tumor-associated antigen and is classified as a cancer-testis antigen. It is expressed in a wide range of malignant tumors including melanoma, non-small cell lung cancer, breast carcinoma, ovarian carcinoma, renal cell carcinoma, and various sarcomas, while remaining largely absent in normal adult tissues—with the exception of testis, ovary, adrenal, and endometrium.

The PRAME antibody (clone EPR20330) offers high sensitivity and specificity for immunohistochemical detection of PRAME expression in formalin-fixed, paraffin-embedded (FFPE) tissue samples. It is particularly valuable in differentiating malignant melanoma from benign nevi and in identifying tumors with potential immunotherapeutic relevance. Nuclear staining provides a clear, interpretable pattern to aid diagnostic confidence.

This prediluted format is optimised for use with standard IHC protocols and is ready to use without additional dilution.

Specifications

Intended Use
IVD

Format
Predilute

Volume
6.0 mL

Source
Rabbit Monoclonal

Clone
EPR20330

Isotype
IgG

Antigen
PRAME protein, encoded on chromosome 22q11.22

Localization
Nuclear

Positive Control
Melanoma or testicular tissue

Species Reactivity
Human

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